Human Indoleamine 2,3-dioxygenase and the CD4+ T Cell Response

Eric Dumas

I am interested in identifying protective immune pathways as well as understanding why some host responses fail to clear genital C. trachomatis infection. To do so, I am characterizing species-specific, cell-autonomous responses that are induced by IFN-γ, with a focus on generating a mouse model for human-like IDO expression. Furthermore, I am interested in examining the effect that kynurenines, the byproduct of tryptophan breakdown by hIDO, have on the CD4+ T cell response.